Here at Calico Biolabs, we've developed a highly effective method of antibody development. Our propriety method allows us to develop high quality antibodies without the use of traditional cell fusion and hybridoma methods. While traditional methods require termination of the animal to harvest the splenocytes, our method only requires routine blood draws; allowing us to collect samples over a time course, throughout the full immune response rather than at a single time point. Our method also allows for higher stability, flexibility, and ease of scaleability than traditional methods, while entirely avoiding the issue of post-translational modification variations when cloning antibodies from hybridomas. In addition, this method has been successful in other vertebrate species, such as chicken, goat, llama, and camel.